Genome Integrity

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 12  |  Issue : 1  |  Page : 1--10

Association of telomere length and serum vitamin D levels with type 2 diabetes mellitus and its related complications: A possible future perspective


C Akash1, Madhav Prabhu1, Arif Maldar1, Poornima Akash2, Sanjay Mishra3, TK Madhura4, Santosh Kumar1, Rekha S Patil1, Shobhit Piplani1, KS Smitha5 
1 Department of General Medicine, Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India
2 Department of Kayachikitsa (General Medicine), Alva's Ayurveda Medical College, Moodbidri, Karnataka, India
3 Dr. Prabhakar Kore Basic Science Research Centre, Belagavi, Karnataka, India
4 Department of Biochemistry, USM-KLE, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India
5 Department of Ophthalmology, Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India

Correspondence Address:
C Akash
Department of General Medicine, Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research, Belagavi - 590 010, Karnataka
India

Evidence show that shortened telomere length (TL) and low Vitamin D levels can increase the risk of type 2 diabetes mellitus (T2DM) and its associated complications. T2DM has been considered as an age-related disease, it may be associated with TL. The study aimed to evaluate the association of TL and Vitamin D levels with complications of T2DM and the impact of Vitamin D on TL in patients with T2DM. This 1-year cross-sectional study was conducted at a tertiary care hospital on 90 patients. Height, weight, body mass index, waist-hip ratio was calculated. Fasting blood sugars, postprandial blood sugar, and glycated hemoglobin (HbA1c) were analyzed. Absolute TL was obtained from quantitative real-time polymerase chain reaction (qPCR). Vitamin D estimation was done by chemiluminescent immunoassay. Descriptive analysis of the data was done using R i386 3.6.3. The study found a positive correlation between TL and Vitamin D levels (r = 0.64; P < 0.0001). The interaction with high HbA1c levels and lower levels of Vitamin D led to the shortening of TL (P = 0.0001). The median of TL and mean of Vitamin D levels were significantly less in the diabetic group (P < 0.0001). Vitamin D levels positively affected the TL and its levels had an inverse relation with the HbA1c levels. This association had a significant effect on the shortening of TL. Vitamin D also had a significant association with other diabetic complications that instigated the shortening of TL. Therefore, assessing the role of Vitamin D levels on the shortening of TL can prove to be crucial biomarkers in managing optimal glycemic levels in T2DM patients.


How to cite this article:
Akash C, Prabhu M, Maldar A, Akash P, Mishra S, Madhura T K, Kumar S, Patil RS, Piplani S, Smitha K S. Association of telomere length and serum vitamin D levels with type 2 diabetes mellitus and its related complications: A possible future perspective.Genome Integr 2021;12:1-10


How to cite this URL:
Akash C, Prabhu M, Maldar A, Akash P, Mishra S, Madhura T K, Kumar S, Patil RS, Piplani S, Smitha K S. Association of telomere length and serum vitamin D levels with type 2 diabetes mellitus and its related complications: A possible future perspective. Genome Integr [serial online] 2021 [cited 2022 Jan 16 ];12:1-10
Available from: https://www.genome-integrity.org/article.asp?issn=2041-9414;year=2021;volume=12;issue=1;spage=1;epage=10;aulast=Akash;type=0