Genome Integrity

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 7  |  Issue : 1  |  Page : 11-

Strong correlation among three biodosimetry techniques following exposures to ionizing radiation


Chang-Mo Kang1, Hyun Jin Yun1, Hanna Kim2, Cha Soon Kim2 
1 Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea
2 Radiation Epidemiology Team, Radiation Health Institute, Korea Hydro and Nuclear Power Co., Gyeonggi-do 13605, Republic of Korea

Correspondence Address:
Chang-Mo Kang
Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 01812
Republic of Korea

Three in vitro dose calibration curves for biodosimetry such as dicentric chromosome assay, fluorescence in situ hybridization (FISH) assay for translocation, and micronuclei (MNs) in binucleated cell assay were established after exposure to ionizing radiation. Peripheral blood lymphocyte samples obtained from healthy donors were irradiated with 60Co source at a dose rate of 0.5 Gy/min to doses of 0.1–6 Gy. The results from three in vitro dose calibration curves for biodosimetry were analyzed to understand the relationship among biodosimetry assay techniques. Our comparison demonstrates that there is a very strong positive correlation among the dicentric assay, FISH, and MNs analysis, and these three biodosimetry assays strongly support the in vitro dose reconstruction and the emergency preparedness of public or occupational radiation overexposure.


How to cite this article:
Kang CM, Yun HJ, Kim H, Kim CS. Strong correlation among three biodosimetry techniques following exposures to ionizing radiation.Genome Integr 2016;7:11-11


How to cite this URL:
Kang CM, Yun HJ, Kim H, Kim CS. Strong correlation among three biodosimetry techniques following exposures to ionizing radiation. Genome Integr [serial online] 2016 [cited 2022 Aug 10 ];7:11-11
Available from: https://www.genome-integrity.org/article.asp?issn=2041-9414;year=2016;volume=7;issue=1;spage=11;epage=11;aulast=Kang;type=0