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Original Article:
Association of telomere length and serum vitamin D levels with type 2 diabetes mellitus and its related complications: A possible future perspective
C Akash, Madhav Prabhu, Arif Maldar, Poornima Akash, Sanjay Mishra, TK Madhura, Santosh Kumar, Rekha S Patil, Shobhit Piplani, KS Smitha
Genome Integr
2021, 12:1 (18 November 2021)
DOI
:10.4103/genint.genint_3_21
Evidence show that shortened telomere length (TL) and low Vitamin D levels can increase the risk of type 2 diabetes mellitus (T2DM) and its associated complications. T2DM has been considered as an age-related disease, it may be associated with TL. The study aimed to evaluate the association of TL and Vitamin D levels with complications of T2DM and the impact of Vitamin D on TL in patients with T2DM. This 1-year cross-sectional study was conducted at a tertiary care hospital on 90 patients. Height, weight, body mass index, waist-hip ratio was calculated. Fasting blood sugars, postprandial blood sugar, and glycated hemoglobin (HbA1c) were analyzed. Absolute TL was obtained from quantitative real-time polymerase chain reaction (qPCR). Vitamin D estimation was done by chemiluminescent immunoassay. Descriptive analysis of the data was done using R i386 3.6.3. The study found a positive correlation between TL and Vitamin D levels (
r
= 0.64;
P
< 0.0001). The interaction with high HbA1c levels and lower levels of Vitamin D led to the shortening of TL (
P
= 0.0001). The median of TL and mean of Vitamin D levels were significantly less in the diabetic group (
P
< 0.0001). Vitamin D levels positively affected the TL and its levels had an inverse relation with the HbA1c levels. This association had a significant effect on the shortening of TL. Vitamin D also had a significant association with other diabetic complications that instigated the shortening of TL. Therefore, assessing the role of Vitamin D levels on the shortening of TL can prove to be crucial biomarkers in managing optimal glycemic levels in T2DM patients.
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Online since 29
th
November, 2014