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Year : 2016  |  Volume : 7  |  Issue : 1  |  Page : 11

Strong correlation among three biodosimetry techniques following exposures to ionizing radiation

1 Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea
2 Radiation Epidemiology Team, Radiation Health Institute, Korea Hydro and Nuclear Power Co., Gyeonggi-do 13605, Republic of Korea

Correspondence Address:
Chang-Mo Kang
Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 01812
Republic of Korea
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2041-9414.197168

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Three in vitro dose calibration curves for biodosimetry such as dicentric chromosome assay, fluorescence in situ hybridization (FISH) assay for translocation, and micronuclei (MNs) in binucleated cell assay were established after exposure to ionizing radiation. Peripheral blood lymphocyte samples obtained from healthy donors were irradiated with 60Co source at a dose rate of 0.5 Gy/min to doses of 0.1–6 Gy. The results from three in vitro dose calibration curves for biodosimetry were analyzed to understand the relationship among biodosimetry assay techniques. Our comparison demonstrates that there is a very strong positive correlation among the dicentric assay, FISH, and MNs analysis, and these three biodosimetry assays strongly support the in vitro dose reconstruction and the emergency preparedness of public or occupational radiation overexposure.

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